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View Code? Open in Web Editor NEWMarkdown version of Reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine
Markdown version of Reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine
Looks like a bit of link rot.
The link in the readme:
https://mednet-communities.net/inn/db/media/docs/11889.doc
...appears dead. Is there another copy?
I suspect (see #3) that RNA folding may play a role in the optimisation.
https://academic.oup.com/nar/article/48/22/12436/5961787
This may be of help: https://www.nature.com/articles/s41467-020-19371-y
ncov-s.fasta and vaccine-s.fasta contain the same sequence which appears to be the virus sequence (if I compare with side-by-side.csv). For example, the first two codons for the vaccine according to side-by-side.csv is ATG-TTC, however if you look at the first two codons in vaccine-s.fasta the first two codons are ATG-TTT.
The README says "All vaccine data here is sourced from this World Health Organization document.", but this document only contains one sequence.
I guess it describes the vaccine because it contains Ψ
, but nowhere does the document mention that. Is there a WHO site anywhere that gives more context?
Where did you get the original virus sequence? And do we know if they started from any particular mutation? I guess they got started as soon as the virus virus sequence was uploaded, but I don't know if they made tweaks later based on mutations seen in the wild?
For the ultra paranoid: maybe put that document in the repo and timestamp it.
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