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[11/16/2020 21:22:29] Warning While calculate c1ccccc1 by model VEGA - Mutagenicity (Ames test) model (KNN/Read-Across): "-1.58" is not a prediction for the declared scale.

Dear all, I get following error. I installed the newest version of the toolbox and when inistiating the OECD server, there is following error. Could you help me to set up VEGA in the toolbox correctly.
Thanks, Romana

[09/15/2023 08:55:08] Error System.TypeLoadException: Method 'get_SuportingChemicals' in type 'VegaAddins.Qsar.PredictionAddin' from assembly 'VegaAddins, Version=1.0.5.0, Culture=neutral, PublicKeyToken=null' does not have an implementation.
[09/15/2023 08:55:08] Error System.TypeLoadException: Method 'AdditionalLists' in type 'VegaAddins.Qsar.TbQsarAddinFactory' from assembly 'VegaAddins, Version=1.0.5.0, Culture=neutral, PublicKeyToken=null' does not have an implementation.
[09/15/2023 08:55:08] Error System.Reflection.ReflectionTypeLoadException: Unable to load one or more of the requested types.
Method 'get_SuportingChemicals' in type 'VegaAddins.Qsar.PredictionAddin' from assembly 'VegaAddins, Version=1.0.5.0, Culture=neutral, PublicKeyToken=null' does not have an implementation.
Method 'AdditionalLists' in type 'VegaAddins.Qsar.TbQsarAddinFactory' from assembly 'VegaAddins, Version=1.0.5.0, Culture=neutral, PublicKeyToken=null' does not have an implementation.
at System.Reflection.RuntimeModule.GetTypes(RuntimeModule module)
at System.Reflection.Assembly.GetTypes()
at Toolbox.Service.Scanner.AddinScanner.SimpleAddinScanner.GetToolboxObjectFactories(String assemblyName, ToolboxEventLogger logger)+MoveNext()
System.TypeLoadException: Method 'get_SuportingChemicals' in type 'VegaAddins.Qsar.PredictionAddin' from assembly 'VegaAddins, Version=1.0.5.0, Culture=neutral, PublicKeyToken=null' does not have an implementation.
System.TypeLoadException: Method 'AdditionalLists' in type 'VegaAddins.Qsar.TbQsarAddinFactory' from assembly 'VegaAddins, Version=1.0.5.0, Culture=neutral, PublicKeyToken=null' does not have an implementation.
[09/15/2023 08:55:09] Error System.Reflection.ReflectionTypeLoadException: Unable to load one or more of the requested types.
Method 'get_SuportingChemicals' in type 'VegaAddins.Qsar.PredictionAddin' from assembly 'VegaAddins, Version=1.0.5.0, Culture=neutral, PublicKeyToken=null' does not have an implementation.
Method 'AdditionalLists' in type 'VegaAddins.Qsar.TbQsarAddinFactory' from assembly 'VegaAddins, Version=1.0.5.0, Culture=neutral, PublicKeyToken=null' does not have an implementation.
at System.Reflection.RuntimeModule.GetTypes(RuntimeModule module)
at System.Reflection.Assembly.GetTypes()
at Toolbox.Service.Scanner.AddinScanner.SimpleAddinScanner.GetToolboxObjectFactories(String assemblyName, ToolboxEventLogger logger)+MoveNext()
at System.Collections.Generic.List1..ctor(IEnumerable1 collection)
at Toolbox.Service.Scanner.AddinScanner.SimpleAddinScanner.GetToolboxObjectFactories(Func2 filter, List1 binFolders, ToolboxEventLogger logger)
System.TypeLoadException: Method 'get_SuportingChemicals' in type 'VegaAddins.Qsar.PredictionAddin' from assembly 'VegaAddins, Version=1.0.5.0, Culture=neutral, PublicKeyToken=null' does not have an implementation.
System.TypeLoadException: Method 'AdditionalLists' in type 'VegaAddins.Qsar.TbQsarAddinFactory' from assembly 'VegaAddins, Version=1.0.5.0, Culture=neutral, PublicKeyToken=null' does not have an implementation.

Hey! I am facing the following error related to the QSAR toolbox server when I am trying to predict the chemical using vega add ins v 1.0.3 as well as v 1.0.5. I have installed all the prerequisites like postgre, .net (4.7.2) java (64bit) at default location (C drive). but I am getting the following error again and again. Please give me sugesstions and help me.
25 February 2021 22:45:09
========== ServerInfo START ==========
Server Mode: SingleUser
Listening on: net.tcp://localhost:8801/WcfRequestProcessor, Local IPC
Database: Toolboxv21R1@localhost
Service State: Opened
Sessions: 1/1
Documents: 1/1
Chemical lists: 4/4
Tree nodes: 335/420
Tasks: 7/39
Server Uptime: 00:02:03
Operating System: Microsoft Windows 10 Home
Platform: 64-bit
Processor: Intel(R) Core(TM) i7-8750H CPU @ 2.20GHz
Installed Memory: 16 GB
Used Memory: 1,212 MB
========== ServerInfo END ==========
========== ErrorLog START ==========
[02/25/2021 22:44:48] Warning While calculate c1ccccc1 by model VEGA - Ready Biodegradability model (IRFMN): Unable to perform Applicability Domain check
[02/25/2021 22:44:39] Error System.NullReferenceException: Object reference not set to an instance of an object.
at net.sf.jni4net.jni.JNIEnv.GetFieldID(Class clazz, String name, String sig)
at net.sf.jni4net.Ref.Init()
at net.sf.jni4net.Bridge.BindCore(JNIEnv env, BridgeSetup newSetup)
at net.sf.jni4net.Bridge.CreateJVM()
at net.sf.jni4net.Bridge.CreateJVM(BridgeSetup setup)
at VegaAddins.Qsar.QsarAddin.RetrieveModelPreD(ITbBasket target, Dictionary2 Modelinfo) in C:\Users\kosmu\Source\Repos\marcabrus\TBVegaAddin\Qsar\QsarAddin.cs:line 177 at VegaAddins.Qsar.QsarAddin.IsRelevantToChemical(ITbBasket target, String& reason) in C:\Users\kosmu\Source\Repos\marcabrus\TBVegaAddin\Qsar\QsarAddin.cs:line 106 at LMC.Toolbox.Server.ObjectManager.TbObjectFactoryWrappers.TbQsarWrapper.IsRelevantToChemical(IWorkBasket target) [02/25/2021 22:44:39] Error net.sf.jni4net.jni.JNIException: Can't initialize proxy java.lang.System ---> System.Reflection.TargetInvocationException: Exception has been thrown by the target of an invocation. ---> java.lang.LinkageError: runFinalizersOnExit at net.sf.jni4net.jni.JNIEnv.ExceptionTest() at net.sf.jni4net.jni.JNIEnv.GetStaticMethodID(Class clazz, String name, String sig) at java.lang.System.InitJNI(JNIEnv __env, Class __class) --- End of inner exception stack trace --- at System.RuntimeMethodHandle.InvokeMethod(Object target, Object[] arguments, Signature sig, Boolean constructor) at System.Reflection.RuntimeMethodInfo.UnsafeInvokeInternal(Object obj, Object[] parameters, Object[] arguments) at System.Reflection.RuntimeMethodInfo.Invoke(Object obj, BindingFlags invokeAttr, Binder binder, Object[] parameters, CultureInfo culture) at System.Reflection.MethodBase.Invoke(Object obj, Object[] parameters) at net.sf.jni4net.utils.Registry.RegisterStaticAndMethods(RegistryRecord record, JNIEnv env) --- End of inner exception stack trace --- at net.sf.jni4net.utils.Registry.RegisterStaticAndMethods(RegistryRecord record, JNIEnv env) at net.sf.jni4net.utils.Registry.BindJvm(RegistryRecord record, ClassLoader classLoader, JNIEnv env) at net.sf.jni4net.utils.Registry.BindJvm(RegistryRecord record, JNIEnv env) at net.sf.jni4net.utils.Registry.RegisterType(Type type, Boolean bindJVM, JNIEnv env) at net.sf.jni4net.utils.Registry.RegisterAssembly(Assembly assembly, Boolean bindJVM) at net.sf.jni4net.Bridge.RegisterAssembly(Assembly assembly) at net.sf.jni4net.Bridge.BindCore(JNIEnv env, BridgeSetup newSetup) at net.sf.jni4net.Bridge.CreateJVM() at net.sf.jni4net.Bridge.CreateJVM(BridgeSetup setup) at VegaAddins.Qsar.QsarAddin.RetrieveModelPreD(ITbBasket target, Dictionary2 Modelinfo) in C:\Users\kosmu\Source\Repos\marcabrus\TBVegaAddin\Qsar\QsarAddin.cs:line 177
at VegaAddins.Qsar.QsarAddin.IsRelevantToChemical(ITbBasket target, String& reason) in C:\Users\kosmu\Source\Repos\marcabrus\TBVegaAddin\Qsar\QsarAddin.cs:line 106
at LMC.Toolbox.Server.ObjectManager.TbObjectFactoryWrappers.TbQsarWrapper.IsRelevantToChemical(IWorkBasket target)
========== ErrorLog END ==========

Logpwith scale "none" can't be used inside a profiler. Update to "continuous"

Hi Team,

Please share details on the timeline by which next version of the Vega plugin compatible with OECD QSAR toolbox 4.5 will be available?

Thanks in advance!

Take care!

Best regards,
Harjinder

I am trying the ECHA PBT screening profiler in the OECD ToolBox and I get this type of error:

LogKow>4.5 screening pot B/vB (storage lipid)
No QSAR prediction can be done (fish BCF VEGA)
Undefined

As you can see from the image, the VEGA addin is installed.
Also from the Data Gap Filling > QSAR I am not able to use the models of VEGA.

Can you help?

Thanks a lot
Elena

[11/15/2020 18:46:14] Warning While calculate c1ccccc1 by model VEGA - Ready Biodegradability model (IRFMN): Unable to perform Applicability Domain check
[11/15/2020 20:06:36] Warning While calculate c1ccccc1 by model VEGA - Hepatotoxicity model (IRFMN): Unable to perform Applicability Domain check
[11/15/2020 20:07:40] Warning While calculate c1ccccc1 by model VEGA - Bee acute toxicity model (KNN/IRFMN): Unable to perform Applicability Domain check

[11/15/2020 20:06:21] Warning While calculate c1ccccc1 by model VEGA - Adipose tissue:blood model (INERIS): "1.19" is not a prediction for the declared scale.

[11/15/2020 18:48:05] Warning While calculate c1ccccc1 by model VEGA - NOAEL (IRFMN/CORAL): "-0.72" is not a prediction for the declared scale.

https://www.vegahub.eu/vegahub-dwn/qmrf/QMRF_MN_INVIVO.pdf
https://www.vegahub.eu/vegahub-dwn/qmrf/QMRF_CHROM_CORAL.pdf
https://www.vegahub.eu/vegahub-dwn/qmrf/QMRF_AROMA_IRFMN.pdf
https://www.vegahub.eu/vegahub-dwn/qmrf/QMRF_ALGAE_NOEC_IRFMN.pdf

[11/15/2020 18:48:59] Warning While calculate c1ccccc1 by model VEGA - Skin Permeation (LogKp) model (Ten Berge): Cant recognize family: Dose Rate (Area) and/or unit: cm/h
[11/15/2020 18:48:41] Warning While calculate c1ccccc1 by model VEGA - Skin Permeation (LogKp) model (Potts and Guy): Cant recognize family: Dose Rate (Area) and/or unit: cm/h