Comments (11)
This is important for producing gpad - see 'annotation preview' or gpad export in noctua. Currently nothing comes up for reactome models - a common source is needed.
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@ukemi @deustp01 @vanaukenk The conversion code currently digs pubmed references out of xrefs on the Reactome entities (pathways, reactions, controllers). These are applied a little haphazardly as they are attached to entities in Reactome and they need to be moved onto relations in go-cam. You can see examples on the BP has_part MF relations for most models.
Should these pubmed references be taken out? In a sense they are redundant with the reactome source reference that I am adding in now which itself includes them.
from pathways2go.
"redundant" as in you already cite the R-HSA-###### identifier of the relevant event as a reference, so a user can follow that ID to the Reactome page that has all the literature references with PMIDs?
If that's what you mean, then yes, exactly, adding the PMIDs to the GO-CAM is redundant and also haphazard because each PMID almost certainly contributes only a part of the total evidence that supports the GO-CAM model and, as discussed fully already, there is no way to figure out computationally which PMID supports which part.
from pathways2go.
Yup that is what I meant. Okay. I will drop the pmids.
from pathways2go.
We need to be sure in our systematic reviews to see how this affects the GPAD output of a model. I suspect that if the reference is removed, no annotation will be generated. If we want annotations from these, we will need to find something to add. @goodb when you tweak your code, does it generate a new model or overwrite an old one? I have created template documents for some of the models that we will review and added them to the folder @huaiyumi created.
Note we should all start watching this repository so no one gets left out of a conversation.
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I see that @goodb already pointed out the GPAD issue above. @vanaukenk do you know what reference is currently cited for Reactome-based annotations in GO?
from pathways2go.
This ticket was generated because the current approach doesn't generate any GPAD. When this is finished, the GPAD should come out fine because all of the relations will have the same reference to the reactome:R-HSA-###### identifier.
from pathways2go.
Pathways are overwritten in noctua-dev when updates are made. I suggest manually crafted example pathways go into the main noctua as it is more stable (you can still tag them as dev).
from pathways2go.
I just checked, it is the URL that is the ref. So theorhetically if all of this works, we should be able to regenerate the Reactome annotation file from the models. That's something we should check. Maybe the annotations will improve. Who knows?
from pathways2go.
Overwritten is good because the link that we put in our review documents will be stable.
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Related Issues (20)
- Review the causal flow between EGFR(s) activity and Src activity
- First step: Import Reactome Pathways for MOD species HOT 6
- Second step: Add existing evidence to imported pathways HOT 1
- Third step: Use Textpresso-like resource to identify papers that could provide evidence for statements that aren't supported by evidence from existing annotations. HOT 1
- Represent enzymatic complex enablers according to GO-CAM spec HOT 11
- Representation of an unknown enabler in Reactome and GO-CAM HOT 6
- Signal/Transit peptides in Reactome (12 confirmed cases) HOT 3
- Suspicious sequence range for UniProtKB:P43251 derived EWASes HOT 1
- Complexes & Sets - info needed for PRO
- Switch on intermediate small molecule instance sharing for Reactome HOT 9
- Sub-sequence termini revisions/review HOT 4
- R-HSA-163765 "ChREBP activates metabolic gene expression" cleanup HOT 1
- GO-CAM reaction labels don't match the Reactome pathway browser
- Reactome: amino acid and PTM mismatches
- To discuss: how to handle Reactome and Yeast Pathways imported GO-CAMs wrt input/output data updates
- Fatty AcylCoA biosynthesis HOT 4
- Only include reactions that are part of a pathway in the GO-CAM imports
- Experiment: Only include chemicals that are causally connected in a model. HOT 2
- Activity node for reaction should be a process if GO BP is curated at Reactome HOT 5
- The direction of transport in model R-HSA-6787639 is backwards HOT 1
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