take out cross pathway links about pathways2go HOT 3 CLOSED

What do you mean by no links to subpathways? Does that mean that in the Reactome representation of axon guidance we won't include Netrin-1 signaling?

from pathways2go.

The idea is that we could only ever see one level of the hierarchy as seen in the Reactome viewer. For axon guidance, you would just see
axon guidance has_part semaphorin interactions
axon guidance has_part NCAM signaling for neurite out-growth
axon guidance has_part Netrin-1 signaling
axon guidance has_part
etc.

You would not see any events from these subpathways (that is the same as now). This change will mainly impact models (e.g. most signaling pathways) that have connections linking to events in other pathways (which are often super or sub pathways).

from pathways2go.

As an example of a model that is strongly affected by this change. See TCF dependent signaling in response to WNT. In order to build up the full picture of this pathway we would really need to find a way to display the information from the many inter-linked pathways from Reactome. I think the bridge model pattern would work but again, requires client development to happen. The only real alternative that I see is to do what we did before and import the connected data into the model - but then we deal with large clouded graphs (which is why Reactome broke it apart in the first place) and massive redundancy across related models.

from pathways2go.