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cc2qe avatar cc2qe commented on September 24, 2024

@ernfrid is it ok to link your Gist here?

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cc2qe avatar cc2qe commented on September 24, 2024

reference #46

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ernfrid avatar ernfrid commented on September 24, 2024

Definitely. Clearly need to go over all this code more.

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cc2qe avatar cc2qe commented on September 24, 2024

Notes on SV representation

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ernfrid avatar ernfrid commented on September 24, 2024

Also, talked to Ira about this on Friday. He suggested we just mimic VCF, but we didn't have time to discuss in detail.

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lganel avatar lganel commented on September 24, 2024

I think another pro for LOB is readability; for precise variants, the start/stop of the BEDPE interval are the bases flanking the breakpoint. For example, if an interval is 1 90 91, the breakpoint is between the base at position 90 and the base at position 91.

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cc2qe avatar cc2qe commented on September 24, 2024

^ that would actually be true of ROB, not LOB. but yeah i see your point

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cc2qe avatar cc2qe commented on September 24, 2024

In support of BPT, pairtopair and prune would be the only scripts affected by this scheme. pairToBed would natively support a BPT scheme.

just checking through the pairtopair source, it looks like this modification would be trivially easy, since it would only require internally iterating the position by 1 base.

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ernfrid avatar ernfrid commented on September 24, 2024

BEDPE file definition - http://bedtools.readthedocs.org/en/latest/content/general-usage.html

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ernfrid avatar ernfrid commented on September 24, 2024

I believe we've agreed to the BPT record. #52 is open to address this.

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ernfrid avatar ernfrid commented on September 24, 2024

#52 was merged. Closing this issue.

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