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ariel

ARIEL (Accumulation of Rare variants Integrated and Extended Locus-specific test) explores the effects of rare variants within complex traits through locus-based analysis.

boat

BOAT (Bayesian Overlap Analysis Tool) identifies variants that are associated with two traits and tests for enrichment (i.e. whether there are more shared associated variants than expected by chance). Only summary statistics are required to implement BOAT.

comet

COMET (Corrected Overlap and Marginal Enrichment Test) is a computationally efficient method for identifying SNP features (e.g. functional annotation) that are predictive of associated SNPs that are shared between traits, while adjusting for the marginal distributions of the traits. COMET also assesses enrichment at the individual trait level. Only summary statistics are required to implement COMET.

cvs

env.mrmega

Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies (GWAS)

flashfm

Flashfm: multi-trait fine-mapping that uses GWAS summary statistics from several traits

flashfm-ivis

flashfm-ivis: interactive visualisation for fine-mapping of multiple quantitative traits

flashfm-tmp

flashfmzoom

flashfmZoom: a tool for joint fine-mapping and exploration of GWAS results in the UK Biobank

mfm

MFM (Multinomial Fine-mapping) fine-maps genetic associations for several diseases with shared controls, in a Bayesian framework that borrows information between the diseases.

mfmextra

Examples of generating simulated data to evaluate MFM (multinomial fine-mapping)

mgflashfm

MGflashfm: joint fine-mapping of genetic association signals in several traits amongst multiple population groups.