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Michal Draminski's Projects

cytometh icon cytometh

CytoMeth tool compiles a set of open source software named in the Roche pipeline guidelines to perform SeqCap Epi data analysis.

expressionlevelssorla icon expressionlevelssorla

This repository contains the R source code created to perform the analysis for the paper "SorLA expression levels in glioma-associated microglia/macrophages are linked to their activation mode"

transcriptionfactorrest icon transcriptionfactorrest

REST acts as a transcriptional repressor of neuronal genes in non-neuronal cells. In some contexts, REST has been reported as a transcriptional activator. We aimed at defining the role of REST in IDH mutation related phenotype in glioma because REST was 1) described as a factor involved in a blockage of cell differentiation and 2) an important oncogenic factor, and knowing that 3) IDH mutations are oncogenic drivers in glioma that cause significant changes in epigenome, leading to block of differentiation. A pair of REST silenced IDH mutant and IDH WT U87 cell lines were used as a model. Whole genome and transcriptome analyses revealed different patterns of REST binding and its proximal TF motifs in IDH mutated and WT cells, and identified the genes downstream of REST related to ECM organization and cell differentiation. This study shows that the REST role in gliomas is dependent on IDH mutation status.

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