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nadavbra avatar nadavbra commented on July 24, 2024

Hi @awesome-crab,

In principle you should be able to train ProteinBERT without GO annotations. You can either feed it with all-zero vectors or any other global features that seem appropriate for your specific use-case. However, the current scripts assume that you create an h5 dataset from UniRef (with GO annotations).

If you are comfortable with writing a little bit of Python code, I think the best solution for you would be to skip the pretraining script and pretrain ProteinBERT using the Python API (using the functions in the pretraining submodule). Specifically I imagine you'd want to override DatasetHandler to load sequences from your file instead of an h5 dataset.

BTW, it's funny that you are interested in training a protein language model for TCR sequences. I've considered working on a very similar project myself. If you think you might be open for collaboration, feel free to send me an email :)
(Of course, if you want to continue working on this project on your own, that's perfectly understandable.)

Best,
Nadav Brandes

from protein_bert.

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