Giter VIP home page Giter VIP logo

Comments (3)

petercombs avatar petercombs commented on July 26, 2024

I think I should filter out the sequences perhaps both before blast and after blast. The ECR11 sequence doesn't give many blast hits outside of primates, so perhaps removing the LINE from that prior to blast will improve the hits in other species.

from mpra_selection.

petercombs avatar petercombs commented on July 26, 2024

Okay, I've now (in commit 6418a80) removed repeats from the data pipeline both prior to blasting (I blast with both the masked and unmasked sequence to get better hits) and after. However, I'm going to run into an issue when I get to the final selection calling, since that assumes that the coordinates in the MPRA data match the human sequence, which they no longer necessarily do.

from mpra_selection.

petercombs avatar petercombs commented on July 26, 2024

Alright, with the latest bolus of commits, I think I have everything fixed. I ran into an additional issue where different regions were getting masked, so I got around that by propagating the masks after a final alignment.

The coordinate issue I solved by reinserting a homo sapiens sequence with a different name, and having all my scripts know not to mask that.

from mpra_selection.

Related Issues (11)

Recommend Projects

  • React photo React

    A declarative, efficient, and flexible JavaScript library for building user interfaces.

  • Vue.js photo Vue.js

    🖖 Vue.js is a progressive, incrementally-adoptable JavaScript framework for building UI on the web.

  • Typescript photo Typescript

    TypeScript is a superset of JavaScript that compiles to clean JavaScript output.

  • TensorFlow photo TensorFlow

    An Open Source Machine Learning Framework for Everyone

  • Django photo Django

    The Web framework for perfectionists with deadlines.

  • D3 photo D3

    Bring data to life with SVG, Canvas and HTML. 📊📈🎉

Recommend Topics

  • javascript

    JavaScript (JS) is a lightweight interpreted programming language with first-class functions.

  • web

    Some thing interesting about web. New door for the world.

  • server

    A server is a program made to process requests and deliver data to clients.

  • Machine learning

    Machine learning is a way of modeling and interpreting data that allows a piece of software to respond intelligently.

  • Game

    Some thing interesting about game, make everyone happy.

Recommend Org

  • Facebook photo Facebook

    We are working to build community through open source technology. NB: members must have two-factor auth.

  • Microsoft photo Microsoft

    Open source projects and samples from Microsoft.

  • Google photo Google

    Google ❤️ Open Source for everyone.

  • D3 photo D3

    Data-Driven Documents codes.