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giovp avatar giovp commented on June 11, 2024

Ideas for evaluation

One way to evaluate is to perform clustering on the spatial graph, and assess whether enriched neighbors are consistent with known stereotypical organization of the brain.
The workflow could be something like:

  • cluster spots in gene expression space: see this tutorial
  • perform enrichment of spatial graph based on label of gene expression space.
  • check that enriched neighbors (either by value or effect size) are consistent with spatial organization of spot clusters

from squidpy.

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