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Repository containing the scripts to perform domain adversarial training of neural networks for classification of rare histological subtypes of osteosarcoma in canines and humans
Statistical analyses describing metastatic outgrowth patterns in Canine Osteosarcomas.
This repository contains the scripts to perform large-scale comparative deconvolution analysis of the canine and human Osteosarcoma tumor microenvironment
utilizing single cell RNA-seq data of different adult brain cell types to discover celltype specific gene function of TCF4
Leveraging Digital Pathology Foundation Models to characterize the tumor microenvironment (TME)
A computational framework for inference of causality in cell-signaling from gene expression data.
Little is known regarding the relationship between intratumor heterogeneity (ITH) and immune response in melanoma. Here we study this question in a novel, controlled experimental UVB mouse melanoma model that enables one to study the effects of intra-tumor heterogeneity on tumor aggressiveness and immune response independently of tumor mutational burden (TMB). The induction of UVB-derived mutations in parental melanoma cell-lines gives rise to high TMB tumors that are highly aggressive accompanied by decreased anti-tumor activity of tumor infiltrating lymphocytes (TILs). However, strikingly, UVB single-cell derived melanoma clones with similar high TMB levels but reduced ITH are swiftly rejected. Their rejection is accompanied by increased TIL reactivity, increased CD8+ T cell core infiltration and a less suppressive microenvironment. Using phylogenetic tree analyses and mixing experiments of 20 single cell UVB clones that lie along the phylogenetic tree we show that tumor rejection is inversely associated with the number of injected clones and their genetic diversity. Notably, similar observations are recapitulated and reinforced in the analysis of melanoma patient data, both in terms of overall melanoma patient survival and in response to immune check point therapy. Taken together, our results highlight the importance of tumor ITH in melanoma and put forward the need to carefully quantify it to more accurately, when evaluating patient survival and response to checkpoint blockade.
A declarative, efficient, and flexible JavaScript library for building user interfaces.
🖖 Vue.js is a progressive, incrementally-adoptable JavaScript framework for building UI on the web.
TypeScript is a superset of JavaScript that compiles to clean JavaScript output.
An Open Source Machine Learning Framework for Everyone
The Web framework for perfectionists with deadlines.
A PHP framework for web artisans
Bring data to life with SVG, Canvas and HTML. 📊📈🎉
JavaScript (JS) is a lightweight interpreted programming language with first-class functions.
Some thing interesting about web. New door for the world.
A server is a program made to process requests and deliver data to clients.
Machine learning is a way of modeling and interpreting data that allows a piece of software to respond intelligently.
Some thing interesting about visualization, use data art
Some thing interesting about game, make everyone happy.
We are working to build community through open source technology. NB: members must have two-factor auth.
Open source projects and samples from Microsoft.
Google ❤️ Open Source for everyone.
Alibaba Open Source for everyone
Data-Driven Documents codes.
China tencent open source team.