Latest version does not work at all about tinyipc HOT 4 CLOSED

That is too little information, it works fine for me in both .NET Framework and .NET 6.

What file does it fail to load? What .NET version are you running? AnyCPU or x86 or x64?

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The code snippet I showed above is literally what causes the exception to be thrown. The Initialize method shown above gets called by another class to create the IPC connection, presumably with a MMF (Memory Mapped File).

Sadly , the exception does not give any further detail.

I don't think it's a physical file. Its an MMF most likely.
It just looks like its failing to create the MMF. MessageBusName is a constant: "HSC.MessageBus".

The .NET Framework ver is 4.8 and its a 64 bit CPU - Ryzen 9 3900x, but the project build setting is set for Any CPU.

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I doubt it, my code isn't even in the stacktrace. It's probably some assembly that is failing to load. You will have to look that up in the exception properties in a debugger to find out which one.

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Since I can't help without knowing more I'm closing this issue.

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