This is supplementary material for:

J. Ha and A. Sherman. 2019. Type 2 Diabetes: One Disease, Many Pathways [PubMed].

pathway.m

pathway_FIG9.m

pathway_FIGS15.m

Figure 1: FIG1.m

Figure 2: FIG2.m

Figure 3: FIG3.m

Figure 4: FIG4.m

Figure 6: FIG6.m

Figure 7: FIG7.m

FigS8: FIGS8.m

FigS9: FIGS9.m

FigS10: FIGS10.m

FigS11: FIGS11.m

FigS12: FIGS12.m

FigS13: FIGS13.m

FigS14: FIGS14.m

FigS14: FIGS15.m

pathway.ode: pathway.ode

pathway_FIG9.ode (insulin reistance induced by insulin): pathway_FIG9.ode

pathway_FIGS10_11.ode (non-insulin dependent glucose uptake): pathway_FIGS10_11.ode

FIG1.set (IGT-first pathway): FIG1.set

FIG2.set (Sustained IGT): FIG2.set

FIG3.set (IFG-first pathway IGT): FIG3.set

FIG4.set (IGT without CGI): FIG4.set

FIG9_no_cl_no_FE.set (default IGT-first pathway; use pathway_FIG9.ode): FIG9_no_cl_no_FE.set

FIG9_modest_cl_FE.set (reduced clearance delays T2D; use pathway_FIG9.ode): FIG9_modest_cl_FE.set

FIG9_balanced_cl_FE.set (reduced clearance and induced resistance cancel out; use pathway_FIG9.ode): FIG9_balanced_cl_FE.set

FIG9_extreme_cl_FE.set (reduced clearance and severe induced resistance accelerates T2D; use pathway_FIG9.ode): FIG9_extreme_cl_FE.set

FIGS8.set (mild GOF KATP defect): FIGS8.set

FIGS9.set: (severe GOF KATP defect): FIGS9.set

FIGS10.set (impaired glucose effectiveness; use pathway_FIGS10_11.ode): FIGS10.set

FIGS11.set (enhanced glucose effectiveness; use pathway_FIGS10_11.ode): FIGS11.set

FIGS12_fast_si.set (IGT-first pathway, same as Fig. 1): FIGS12_fast_si.set

FIGS12_slow_si.set (protected from T2D): FIGS12_slow_si.set

FIGS13.set (IFG-first pathway driven by GOF KATP defect): FIGS13.set

FIGS14.set: (IFG-first pathway driven by impaired vesicle trafficking - small RRP): FIGS14.set

FIGS15.set (impaired incretin signaling accelerates T2D): FIGS15.set