ProTINA (Protein Target Inference by Network Analysis) is a network-based analytical tool for identifying protein targets of compounds from gene transcriptional profiles. ProTINA scores proteins according to the enhancement or attenuation of the protein-gene regulatory interactions caused by a compound treatment. The magnitude of the scores indicates the degree of compound-induced alterations in the gene regulatory activity of a protein, while the sign of the scores indicates the direction of the alterations (positive: enhancement, negative: attenuation). In ProTINA, the protein targets of a compound are ranked according to the magnitudes of the protein scores.

MATLAB and R versions of ProTINA are available. Please refer to ProTINA manuscript for more detailed information.

For MATLAB distribution,

• MATLAB® R2014b or later
• GLMNET package

For R distribution,

• R software (>=3.4.1)
• devtools package in R

• MATLAB package: version 1.0 (10.10.2017)
• R package: version 1.0 (10.10.2017)

Redistribution and use in source and binary forms, with or without modification, are permitted provided agreeing to the Simplified BSD Style License (see more).

License (RTF, 2 KB)

Please refer to README for MATLAB and README for R.

This work has been supported by the ETH Zurich Research Grant.