Mutational signature analysis of WGS data. This repo constains simple scripts to perform mutational signatures analysis using SigProfilerExtractor

the script "add_ref_signatures.py" stored in aux_script directory provide examples to donwload the reference genome (def:GRCh38)

The makefile stored in aux_scripts directory provide examples for mutect and strelka callers.

The python and bash scripts provide examples for both Point mutations callers.

The python script run_cnv_signature.py and the bash script runsig_both.sh stored in the aux_script directory provide examples for discovering CNV signatures from Purple or Facets callers.

To avoid install the needed software a Docker container is available at hub.docker:iarcbioinfo/mutsig and include the GRCh38 reference.