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fungal_drug_synergy's Introduction

Fungal_Drug_Synergy

Different pathways mediate amphotericin-lactoferrin drug synergy in Cryptococcus and Saccharomyces

Figures

Figure 1.

1a.

List of selected GO terms: compare_cneo_scer/Data/Selected_GO_Terms/list_of_selected_GO_terms.txt Plotting Script: compare_cneo_scer/Source/Compare_Global_Enrichment/compare_go_terms.Rmd

1b.

Plotting Script: compare_cneo_scer/Source/Compare_Orthologs/compare_orthologs.Rmd

Figure 2.

2a.

Plotting Script: cneo_synergy/Source/Compare_Fold_Change/compare_A_AL_fold_change.Rmd

2b.

Analyse specific gene sets: cneo_synergy/Source/Functional_Enrichment/go_enrichment_specific_set.Rmd Plotting Script: cneo_synergy/Source/Compare_Fold_Change/plot_selected_GO_terms.Rmd

Figure 3.

3a and b.

Script for generating Self-Organising Maps and Gene Ontology Enrichment Analysis of each cluster: cneo_synergy/Source/Self_Organising_Maps/EdgeR_RUVs_QL_choose_k/soms_analysis_EdgeR_RUVs_QL_choose_k.Rmd

Plotting Script: cneo_synergy/Source/Self_Organising_Maps/EdgeR_RUVs_QL_choose_k/draw_soms_using_ggplot.Rmd

Supplementary Information

C. neoformans and S. cerevisiae orthologs information are located in this link. Those in reliability class 1 were identified using BlastP reciprocal top-hits and are one-to-one orthologs. Those in reliability class 2 were orthologs from OrthoMCL, these are not necessarily one-to-one orthologs but could be.

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