Comments (2)
Hi,
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It appears there may be a frame-shift somewhere in the sequence, leading to a stop-codon within the CDR3 region. While I'm not certain, I suspect that RTCR translates the CDR3 region in isolation from the rest of the sequence, potentially overlooking non-functional CDR3s. Do any of the covered regions exhibit a frame-shift?
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I'm not entirely clear on what you mean by "wider coverage." Could you provide a detailed example or elaborate further on this point? Your additional information will help me respond more accurately.
Sincerely,
Mark
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Will close for now. Feel free to reopen.
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