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View Code? Open in Web Editor NEWFitting DNA single-molecule force-extension curves in MATLAB
License: MIT License
Fitting DNA single-molecule force-extension curves in MATLAB
License: MIT License
This is the FDFIT package, for working with DNA force-extension data in MATLAB. GETTING STARTED =============== In the "Doc" directory, you'll find a number of sample scripts. Start with "Tutorial" for the basics. A formatted version of the sample scripts (including figures) can be found in the "Doc\html" directory ("Tutorial.html", etc.) REQUIREMENTS ============ MATLAB R2012a or higher (tested with R2014b), including the following Toolboxes: - Curve Fitting Toolbox; - Optimization Toolbox; - Parallel Computing Toolbox (optional). CREDITS ======= This code was written by Onno Broekmans, during his PhD research in the lab of prof. Gijs J.L. Wuite [1]. Prof. Wuite is the corresponding author on the publication (see "CITATIONS.txt"). The FDFIT package includes some additional libraries, under the "Lib" directory: - cursors.m, by T. Montagnon; - GUI Layout Toolbox, by Ben Tordoff / The Mathworks; - TDMSReader, by Jim Hokanson. See the respective README/LICENSE files for details. Thanks to these people for making their code available for re-use! PERFORMANCE NOTES ================= The analyses in this package have been run on a pretty powerful workstation (2x 8-core Intel Xeon CPU, 32 GB RAM), so not a lot of effort has been invested in optimizing the code for performance. Reproducing the figures from the paper is therefore likely to require at least an overnight run on an 'average' PC. The code does make extensive use of parallel processing (MATLAB's "parfor" loop). You will need the "Parallel Computing Toolbox" for this to work properly (highly recommended). Without that Toolbox, the "parfor" loops will fall back to a normal "for" loop, which is much slower. REPRODUCING THE FIGURES FROM THE PAPER ====================================== Reproducing all the figures from the paper's main text [2] and Supplementary Information should be as easy as opening this folder in MATLAB, and running: >> init >> reproducePaper Then follow the on-screen instructions. NOTE: You will need to have downloaded the paper's raw data from Figshare [3] for this to work. REFERENCES ========== [1]: http://www.nat.vu.nl/~gwuite/ [2]: O.D. Broekmans, G.A. King, G.J. Stephens, G.J.L. Wuite, DNA Twist Stability Changes with Magnesium(2+) Concentration, Phys. Rev. Lett. 116 (2016), 258102. https://doi.org/10.1103/PhysRevLett.116.258102 [3]: O.D. Broekmans, G.A. King, G.J. Stephens, and G.J.L. Wuite, "Double-stranded DNA force-extension data, as a function of magnesium concentration." http://dx.doi.org/10.6084/m9.figshare.1299526 (2015).
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