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pediatric_qualification_package_p-gp_ontogeny's Introduction

Pediatric Qualification Package P-gp Ontogeny

In this repository the electronic package for qualification of P-gp ontogeny using in vivo probe substances are stored, including

  • Input files (qualification plan, report text modules and observed data)

For the Qualification of the P-gp mediated transport of compounds, the following probe substance was included:

  • Digoxin [1]

Necessary software to execute the qualification workflow (see http://setup.open-systems-pharmacology.org for download links and instructions):

  • QualificationRunner
  • Reporting-Engine
  • Markdown-joiner

References

[1] Digoxin-Model, Whole-body PBPK model of Digoxin.

pediatric_qualification_package_p-gp_ontogeny's People

Contributors

incei avatar yuri05 avatar

Forkers

incei yuri05

pediatric_qualification_package_p-gp_ontogeny's Issues

Fix workflow.R

Comment out task inactivation (currently all but 1 tasks are deactivated - workflow will crash).

#' Activate/Deactivate tasks of qualification workflow prior running
workflow$inactivateTasks("simulate")
workflow$inactivateTasks("calculatePKParameters")
workflow$inactivateTasks("plotTimeProfiles")
workflow$inactivateTasks("plotComparisonTimeProfile")
workflow$inactivateTasks("plotGOFMerged")
# workflow$inactivateTasks("plotPKRatio")
workflow$inactivateTasks("plotDDIRatio")

Remove unused code

#workflow$plotPKRatio$settings$units$<PK parameter name> <- <PK parameter unit>
#workflow$plotPKRatio$settings$units$C_max <- "ng/mL"

Wrong chapter?

somehow this chapter seems either wrong in place here, or something is missing
grafik

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