Modeling of published clinical Rifampicin-Rosuvastatin-DDI studies for model evaluation
Within this repository, we share a PK-Sim project file containing simulations of all published clinical studies used to develop and evaluate the predictive performance of our model regarding the Rifampicin-Rosuvastatin-DDI, including the respective observed data. For further details and documentation please refer to [1].
PK-Sim Version 9.1.
The model is distributed under the GPLv2 License.
[1] Hanke N, Gómez-Mantilla JD, Ishiguro N, Stopfer P, Nock V. Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions. Pharmaceutical Research 2021. PMID: 34664206. https://doi.org/10.1007/s11095-021-03109-6