TF Enrichment Scores about dorothea HOT 2 CLOSED

Hi @jamrute,

indeed a positive enrichment score means that the target genes of your TF are enriched at the top ranks of your expression profile and vice versa.

Just a small idea what you can try if you would want to find differences in TF activity between cell types. Assuming you have a Seurat object you can directly run the run_viper() function on your object. Then you can change the assay to dorothea, set the identities to your cell types and run FindAllMarkers(). This will return you a list of differentially activated TFs. Same workflow is for sure also possible if you are working with the SingleCellExperiment object.

from dorothea.

Thank you @christianholland . This was an interesting idea, and I ran the Find All Markers DGE using the Viper scores.

from dorothea.