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wave3's Introduction

wave3

wave3 is a small program used in Beleza S, Santos AM, McEvoy B, Alves I, Martinho C, Cameron E, Shriver MD, Parra EJ, Rocha J (2013). The timing of pigmentation lightening in Europeans. Molecular Biology and Evolution, 30(1): 24-35.

Running

$ wave3 <configuration_file> <results_file>

It produces a resulting text (ASCII) file with nine columns, and a line for each simulation that succeeded. The columns represent

  1. s_number total number of haplotypes carrying the mutation S
  2. different_s number of different mutant S haplotypes
  3. original_s number of haplotypes similar to the original one (11111111S11111111)
  4. heter heterozigozity
  5. p p, or the frequency of original mutant haplotyypes within mutant haplotypes
  6. size population size
  7. sel_coef selection coeficient
  8. g generation when the simulation stopped (all stop criteria reached)
  9. s_freq frequency of the mutant (S) haplotype
s_number;different_s;original_s;heter;p;size;sel_coef;g;s_freq
1477;8;73;0.724853;0.0494245;2756;0.0124275;398;0.535922
1058;10;91;0.728926;0.0860113;2284;0.0319153;143;0.463222
1533;8;83;0.653928;0.0541422;2553;0.0327738;284;0.60047
1376;10;163;0.730048;0.118459;2676;0.0148885;352;0.5142
...

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