Cell tracking using deep neural networks with multi-task learning

Copyright (C) Tao He, Hua Mao, and Zhang Yi. All rights reserved. The code is based on NaiYan Wang, thanks to him for sharing his code. The CNN source code comes from matlab toolbox.

Cell tracking plays crucial role in biomedical and computer vision areas. As cells generally have frequent deformation activities and small sizes in microscope image, tracking the non-rigid and non-significant cells is quite difficult in practice. Traditional visual tracking methods have good performances on tracking rigid and significant visual objects, however, they are not suitable for cell tracking problem. In this paper, a novel cell tracking method is proposed by using Convolutional Neural Networks (CNNs) as well as multi-task learning (MTL) techniques. The CNNs learn robust cell features and MTL improves the generalization performance of the tracking. The proposed cell tracking method consists of a particle filter motion model, a multi-task learning observation model, and an optimized model update strategy. In the training procedure, the cell tracking is divided into an online tracking task and an accompanying classification task using the MTL technique. The observation model is trained by building a CNN to learn robust cell features. The tracking procedure is started by assigning the cell position in the first frame of a microscope image sequence. Then, the particle filter model is applied to produce a set of candidate bounding boxes in the subsequent frames. The trained observation model provides the confidence probabilities corresponding to all of the candidates and selects the candidate with the highest probability as the final prediction. Finally, an optimized model update strategy is proposed to enable the multi-task observation model for the variation of the tracked cell over the entire tracking procedure. The performance and robustness of the proposed method are analyzed by comparing with other commonly-used methods. Experimental results demonstrate that the proposed method has good performance to the cell tracking problem.

If you reuse our codes or our dataset, please cite our paper: url = "http://www.sciencedirect.com/science/article/pii/S0262885616302001",

@article{HE2017142, title = "Cell tracking using deep neural networks with multi-task learning", journal = "Image and Vision Computing", volume = "60", pages = "142 - 153", year = "2017", note = "Regularization Techniques for High-Dimensional Data Analysis", issn = "0262-8856", doi = "https://doi.org/10.1016/j.imavis.2016.11.010", author = "Tao He and Hua Mao and Jixiang Guo and Zhang Yi", }

please matlab run run_MTT.m

All 80 labeled cell sequences are in "samples" directoty, the label file is samples/groundtruth.mat

The main network setting is implemented in initMTT.m. Network training using CNN/cnntrain.m

Implemented in pos_queue.m

We public three results in "results" directory. Three plotting method are supported in get_location.m, get_precision_plot.m, and get_success_plot.m

More details please refer to our paper: url = "http://www.sciencedirect.com/science/article/pii/S0262885616302001"