I have the same motherboard and was looking at your VS code. First question is does it work? I don't have a sensor mounted yet nor do I want filament run-out yet. Something stuck out that you have E2 and X2 activated in the Stepper Driver area of config.h. I would be willing to help with this since no one else has tried this but us two (lol).

/**

• Stepper Drivers
• These settings allow Marlin to tune stepper driver timing and enable advanced options for
• stepper drivers that support them. You may also override timing options in Configuration_adv.h.
• A4988 is assumed for unspecified drivers.
• Options: A4988, A5984, DRV8825, LV8729, L6470, L6474, POWERSTEP01,

•      TB6560, TB6600, TMC2100,
  

•      TMC2130, TMC2130_STANDALONE, TMC2160, TMC2160_STANDALONE,
  

•      TMC2208, TMC2208_STANDALONE, TMC2209, TMC2209_STANDALONE,
  

•      TMC26X,  TMC26X_STANDALONE,  TMC2660, TMC2660_STANDALONE,
  

•      TMC5130, TMC5130_STANDALONE, TMC5160, TMC5160_STANDALONE
  

• :['A4988', 'A5984', 'DRV8825', 'LV8729', 'L6470', 'L6474', 'POWERSTEP01', 'TB6560', 'TB6600', 'TMC2100', 'TMC2130', 'TMC2130_STANDALONE', 'TMC2160', 'TMC2160_STANDALONE', 'TMC2208', 'TMC2208_STANDALONE', 'TMC2209', 'TMC2209_STANDALONE', 'TMC26X', 'TMC26X_STANDALONE', 'TMC2660', 'TMC2660_STANDALONE', 'TMC5130', 'TMC5130_STANDALONE', 'TMC5160', 'TMC5160_STANDALONE']
  */
  #define X_DRIVER_TYPE TMC2130
  #define Y_DRIVER_TYPE TMC2130
  #define Z_DRIVER_TYPE TMC2130
  #define X2_DRIVER_TYPE TMC2130
  //#define Y2_DRIVER_TYPE A4988
  //#define Z2_DRIVER_TYPE A4988
  //#define Z3_DRIVER_TYPE A4988
  //#define Z4_DRIVER_TYPE A4988
  #define E0_DRIVER_TYPE TMC2130
  #define E1_DRIVER_TYPE TMC2130
  #define E2_DRIVER_TYPE TMC2130
  //#define E3_DRIVER_TYPE A4988
  //#define E4_DRIVER_TYPE A4988
  //#define E5_DRIVER_TYPE A4988
  //#define E6_DRIVER_TYPE A4988
  //#define E7_DRIVER_TYPE A4988