zer0o0 / liu2022_bmi1 Goto Github PK

Spermatogenesis is sustained by the homeostasis of self-renewal and differentiation of undifferentiated spermatogonia throughout life, which is regulated by transcriptional and post-transcriptional mechanisms. The mechanistic underpinnings of how BMI1 regulates spermatogonia fate are little known. Our study reveals that BMI1 safeguards undifferentiated spermatogonia fate through multi-functional roles in regulating gene expression programs of undifferentiated spermatogonia.

• snakefiles
  Snakemake workflows for NGS analysis, including ChIP-seq and RNA-seq.
• R
  Scripts for data visualization using R packages.