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This repository provides the MATLAB scripts for our quantitative systems pharmacology model published in Front. Bioeng. Biotechnol., where we conduct an in silico clinical trial in breast cancer using anti-PD-1, anti-CTLA-4 antibody and an epigenetic modulator.

Home Page: https://doi.org/10.3389/fbioe.2020.00141

MATLAB 100.00%
quantitative-systems-pharmacology systems-biology breast-cancer immuno-oncology computational-modeling in-silico-clinical-trial

wang_et_al_2020's Introduction

To initiate the model, run /sciprts/immune_oncology_model.m All parameters are defined in /model/default_parameters_TNBC.m Parameters and reactions for each species are read and added into the model by each module in /model

To run in silico clinical trials, use /sciprts/PSA_script_HW.m Parameter ranges and distributions from which virtual patients are drawn are defined in /postprocessing/PSA_param_in_HW.m

For further questions, please contact the author: Hanwen Wang, [email protected]

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